Learn About Exosomes and Cardiovascular Medicine

Cardiomyopathy & Heart Failure

Cardiomyopathy & Heart Failure

Cardiomyopathy is a condition characterized by diminished output of the heart muscle that may result from ischemic, infectious, hypertrophic or drug-related etiologies. When the cardiac output declines to a sufficient extent, it may result in a condition commonly known as heart failure, which can be fatal. The pathophysiology of cardiomyopathy may include inflammatory, ischemic, apoptotic and genetic mechanisms.

MSC exosomes have the potential to restore the ejection fraction and
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2018 2017
Diagnosis

Diagnosis

Alterations in the number and contents of endogenous exosomes in circulation and secreted in body fluids may provide an opportunity for advanced exosome-based diagnostic modalities. In acute myocardial infarction, inflammation-induced endothelial cell-derived exosomes in plasma have significantly altered miRNA profiles. Cardiomyocyte-derived exosome numbers fluctuate in response to cardiac injury and ischemia may cause a decrease in platelet-derived exosomes. In atherosclerosis, miR-21 and miR-155, which mediate pro-inflammatory effects, are upregulated in immune cell-derived exosomes. miR-155 has been reported to have pro-atherogenic effects. Deficiency of miR-155 in murine models results in reduced
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2019
MYOCARDIAL INFARCTION

Myocardial Infarction

Obstruction or occlusion of the blood supply to the heart muscle can cause myocardial infarction (MI), more commonly known as a heart attack. This potentially deadly cardiovascular event causes symptoms of crushing chest pain, shortness of breath and sometimes pain radiating to the left arm. Though these characteristic symptoms are not always present, MI generally indicates the presence of underlying coronary artery disease, a subtype of vascular disease affecting the arteries that supply the heart muscle. There are multiple genetic, dietary, and lifestyle-related factors that may increase the risk of a heart attack, but at the core mechanism of disease lies chronic inflammation, which causes damage to the inner walls of the
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Vascular Disease

Vascular Disease

Vascular disease is a progressive disorder of the circulatory system that is generally caused by atherosclerosis, which is characterized by damage to the arterial walls. Symptoms of vascular disease may include limb pain or numbness, chest pain or neurologic symptoms related to ischemia of the brain. Vascular disease may be related to genetics, diabetes, high cholesterol, high blood pressure, obesity, physical inactivity and smoking, but central to the pathophysiology of the disease is chronic inflammation, which causes endothelial dysfunction and structural changes to the blood vessels.

MSCs exosomes may offer therapeutic benefits in vascular disease by
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2019 2018

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