Learn About Exosomes and Skin Disorders

Burns

MSC exosomes significantly accelerate re-epithelialization, with increased expression of CK19, PCNA, collagen I compared to collagen III, in vivo (demonstrated with mouse models), promote proliferation of wound healing cells and inhibit apoptosis of skin cells after heat-stress in vitro through activation of AKT pathway. Burn injury significantly increases the inflammatory reaction with increased TNF-α, IL-1β levels and decreased IL-10 levels. MSC exosomes reverse this reaction, in part through miR-181c, suppressing the TLR4 signaling pathway and alleviating inflammation.
2019 2016 2015
Dermatitis

Dermatitis

Many people and patients are plagued by itchy, red, swollen, scaly, cracked skin. Some of these conditions include familiar skin disorders such as eczema, psoriasis, atopic and seborrheic dermatitis, which are characterized by inflammation of the skin. They may begin in childhood and change in severity over the years, and affected people have an increased risk of skin infections. Some of the causes are believed to be genetics, immune system dysfunction, environmental exposures, and may involve a mixture of type I and type IV hypersensitivity reactions.

Mesenchymal stem cell-derived exosomes (MSC exosomes) with their intrinsic anti-inflammatory and immunomodulatory seem to have the potential to
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2019
hair

Hair

Hair loss (alopecia) is a common problem affecting both men and women, and is caused by genetics, hormonal changes, medical condition or medication. Exosomes from MSCs may regulate the hair follicle development and hair growth. In addition to inducing an anagen phase-recruitment effect (increased number of hair follicles in the growth phase), MSC exosomes also enhance the proliferation of dermal papilla cells. These cells are the origin of the cells that produce the hair follicle, which means that dormant hair follicles could begin to produce hair again.
2019
scar

Scar

Reducing or preventing scar formation during wound healing after traumatic, surgical or burn-induced injuries is principal goal of clinical interventions. MSC exosomes have been demonstrated to reduce scar formation and myofibroblast accumulation in skin-defect mouse models, dependent on exosomal microRNAs. Specific microRNAs (miR-21, -23a, -125b, and -145) play key roles in suppressing myofibroblast formation by inhibiting the TGF-β2/SMAD2 pathway.

Αpplication of perinatal MSC exosomes presents a strategy to prevent scar formation by inhibiting excess alpha-smooth muscle actin and collagen deposition and increasing gene expression of N-cadherin, cyclin-1, PCNA and
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2016 2015

UV Damage

Exposure to the ultraviolet radiation from the sun causes damage to the skin that may range from acute sunburn to dyschromia and skin cancer. UV radiation damages collagen fibers and increases melanin production accelerating the appearance of aging of the skin. UVA and UVB light causes degradation of vitamin A in skin, which causes further skin damage and can cause direct DNA damage. Exposure to UV light can produce highly-reactive oxygen radicals, which can damage DNA causing single- and double-strand disruption of DNA. Dimerization of DNA can induce programmed cell death (apoptosis) or cause DNA replication errors causing mutation
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2019

Wound Healing

Wound healing is a complex process involving cell death, migration, proliferation, differentiation, inflammation, and extracellular matrix remodelling. MSC exosomes possess potent immunomodulatory properties and facilitate tissue repair. They may be internalized by fibroblasts to stimulate cell migration, proliferation and collagen synthesis in a dose-dependent manner. In vitro, fibroblasts, keratinocytes and endothelial cells demonstrate significant improvement in proliferation and migration responses in the presence of MSC exosomes. Exosomal growth factors (HGF, IGF1, NGF, SDF1) miRNAs (miR-let-7a-5p, miR-10a-5p, miR-10b-5p, miR-21-5p, miR-22-3p, miR-100-5p, miR-143-3p, miR-146a, miR-191-5p, miR-181a-5p,
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2019 2018 2017 2016 2015

Exosomes Education

Learn about the cellular and molecular biology of exosomes from world-leading exosome scientists.

Discover the potential of exosomes for diagnostic and therapeutic clinical applications and the latest developments in exosome clinical research from physicians and surgeons.

Experience live exosome production and analysis including protein & RNA sequencing, flow cytometry, Nano Tracking Analysis, dSTORM super-resolution fluorescence microscopy and cellular bioassays.